History, variants and usage of the “Morrison equation” in enzyme inhibition kinetics
نویسنده
چکیده
The term “Morrison equation” has varied meaning in the works published by different researchers in enzyme kinetics. This technical note summarizes the historical variants and predecessors of the “Morrison equation” as published by Ackermann & Potter (1949), Morrison (1969), Cha (1975) and Greco & Hakala (1979). Attention is also given to relatively recent textbook treatments by Copeland (2010, 2013). The disparate mathematical formalisms are first converted to a unified algebraic notation and then compared with respect the type of experimental data (i.e., either absolute or fractional rates) that are required to utilize the given algebraic form. A comparison is also made with respect to the implied inhibition mechanism, if any, as well as the number and type of optimized model parameters in nonlinear regression.
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